Bioreactor & Fermentor
Bioreactor & Fermentor
Packed-bed
In a packed-bed basket impeller, cells are immobilized on or entrapped in a three-dimensional matrix.
The basket is comprised of two horizontally positioned, perforated metal plates that extend to the vessel walls.
Enclosed between the plates, Fibra-Cel disks or other matrices form a solid bed for cell growth.
Cells within the bed are protected from external shear forces.
A hollow impeller tube circulates medium, with discharge ports positioned above the basket.
As the tube rotates it creates a small negative pressure at the bottom, drawing culture broth into the tube for recirculation.
Packed-bed impellers are primarily used for manufacturing high-yields of secreted products from suspension cells or anchorage-dependent cultures in continuous cultivation.
The basket is comprised of two horizontally positioned, perforated metal plates that extend to the vessel walls.
Enclosed between the plates, Fibra-Cel disks or other matrices form a solid bed for cell growth.
Cells within the bed are protected from external shear forces.
A hollow impeller tube circulates medium, with discharge ports positioned above the basket.
As the tube rotates it creates a small negative pressure at the bottom, drawing culture broth into the tube for recirculation.
Packed-bed impellers are primarily used for manufacturing high-yields of secreted products from suspension cells or anchorage-dependent cultures in continuous cultivation.
